Journal of Hematology & Oncology is the official journal of the Chinese American Hematologist and Oncologist Network.
Drugging the unfolded protein response in acute leukemias
The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical n...