Table 1 Prognostic genes regulated by DNA methylation identified in AML by genome-wide, large sample studies

Figueroa et al. [16]

HELP

344 Newly diagnosed AML

BLR1 (CXCR5), BTBD3, E2F1, FAM110A, FAM30A, GALNT5, KIAA1305, LCK, LMCD1, PRMT7, SLC7A6OS, SMG6, SRR, USP50, VWF, ZFP161

Li et al. [9]

ERRBS

138 Paried AML (diagnosis and relapse)

CCDC85C, CHL1, ELAVL2, FAM115A, FAM196A, GPR146, GPR6, HELZ2, ID4, IL2RA, KCNG3, LOC254559, LOC284801, NPAS2, PCDHAC2, PROB1, SHISA6, SLC18A3, SOCS2, TRIM67, ZFP42

Marcucci et al. [50]

MethylCap-seq

134 CN-AML (355 CN-AML validated)

AATK, ACAP3, ADCK2, ADCY6, AGPAT9, AHCY, ALOX15B, ANXA6, APBB1, APOD, AQP11, ARHGAP27, AXL, BRF1, C15orf62, C17orf77, C8orf51, CABLES1, CARD11, CD34 ^a, CHMP7, CISH, CLDN15, CLEC3B, DDIT4, DHCR24, DHRS12, EGFL7, ETS1, EVC, F2RL1 ^a, FAM92A1 ^a, FCHO1, FKBP4, FLVCR1, FLVCR1-AS1, FZD6, GAL3ST3, GCNT2, GIT1, GPR56, H1F0, HCN2, HIVEP3, IQSEC1, KCNK6, KDM2B, KLHL3, KNCN, LOC646627, MDFI, ME3, MEOX1, MIR126, MIR155HG ^a, MVD, NAV1, NBL1, NLRP1, PLK3, PMM1, PRKCZ, PRKG2, RAB36, RGS3, RHOC ^a, RHPN1, SCARF1, SCRN1 ^a, SH3TC1, SPRY1, SRC, TBL2, TCEA3, TENC1, UBXN6, VWA8 ^a, WDR16, WDR86, WRAP53, ZNF623, ZNF70