Compound | Target | Combined therapy | Outcomes | Reference |
---|---|---|---|---|
BAY-876 | GLUT1 | NA | Inhibit proliferation | [258] |
WZB117 | GLUT1 | 5-Fu | Reduce 5-Fu resistance | [261] |
2-DG | HK | 5-Fu/Oxaliplatin | Increase chemosensitivity, inhibit migration | [265] |
Gossypol | LDHA | 5-Fu | Increase chemosensitivity, inhibit tumor growth in vivo and vitro | |
Dichloroacetate | PDK | 5-Fu/Oxaliplatin | Increase chemosensitivity, inhibit tumor growth in vivo and vitro | |
AZD3965 | MCT1 | NA | Inhibit growth and glycolysis | [276] |
SLC-0111 | CAIX | 5-FU | Increase chemosensitivity, inhibit tumor growth |