Table 1 clinical and pathological characteristics of AMEs
From: HRAS is a therapeutic target in malignant chemo-resistant adenomyoepithelioma of the breast
Case | Age | Size (mm) | Category | Architecture | Myoepithelial cells | Mitosis /mm2 | Cytologic atypia | Necrosis | Metaplasia/ Associated findings | HER2 | ER, PR | Follow-up (mo) | Recurrence/metastasis | HRAS | PIK3CA | AKT1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T1 | 64 | 9 | Benign | Tubular | Clear | 0 | Mild | Present | Squamous, sebaceous | 0 | ER + PR + | NA | NA | Q61R | w.t | w.t |
T2 | 53 | 15 | Benign | Tubular | Clear | 1 | Mild | Absent | 0 | ER + PR + | NA | NA | w.t | H1047R | w.t | |
T3 | 38 | 24 | Benign | Tubular | Clear | 1 | Moderate | Absent | Squamous | 0 | ER + PR + | NA | NA | w.t | w.t | E17K |
T4 | 62 | 15 | Benign | Tubular | Clear | 1 | Mild | Present | 0 | ER + PR- | 15 | No | w.t | w.t | w.t | |
T5 | 63 | 12 | Benign | Tubular, lobulated, papillary | Clear | 1 | Mild | Absent | 0 | ER + PR- | 36 | No | w.t | w.t | E17K | |
T6 | 37 | 18 | Benign | Tubular, lobulated, papillary, cystic | Clear | 1 | Mild | Absent | Squamous, chondroid and myxoid matrix | 0 | ER + PR- | 9 | No | w.t | w.t | E17K |
T7 | 70 | 9 | Benign | Tubular | Clear | 1 | Moderate | Absent | 0 | ER + PR- | 91 | Recurrence | w.t | w.t | E17K | |
T8 | 36 | 20 | Benign | Tubular | Clear, spindle | 0 | Mild | Absent | 0 | ER- PR- | NA | NA | w.t | H1047R | w.t | |
T9 | 66 | 16 | Benign | Tubular, lobulated | Clear | 0 | Mild | Absent | 0 | ER- PR- | 6 | No | w.t | w.t | ||
T10 | 84 | 25 | Malignant | Tubular, lobulated | Clear | 3 | Severe | Present | 0 | ER + PR- | 12 | Recurrence | G13R | w.t | w.t | |
T11 | 76 | 18 | Malignant | Tubular, lobulated | Clear | 3 | Moderate | Present | 0 | ER- PR- | NA | NA | G13R | H1047R | w.t | |
T12 | 60 | 19 | Malignant | Tubular, spindle, cystic | Clear, spindle | 6 | Severe | Present | 0 | ER- PR- | 75 | No | G13R | H1047R | w.t | |
T13 | 55 | 55 | Malignant | Tubular | Clear | 10 | Severe | Absent | 0 | ER + PR- | 11 | Metastasis | G12S | w.t | w.t |