Fig. 6

The effects of macrophage depletion on BsAb directed T cell trafficking and in vivo anti-tumor response. A Luciferase transduced T cells [Luc(+) T cells] or Luciferase transduced GD2-BsAb armed T cells [Luc(+) GD2-EATs] were administered with anti-CSF1R antibody or clodronate liposome (CL) to the mice bearing neuroblastoma patient-derived xenograft (PDX). B Bioluminescence in the lesions of tumor was monitored. The bioluminescence images on day 7 and quantification of the bioluminescence in the lesions of tumor. C In vivo anti-tumor response by GD2-EATs with anti-CSF1R antibody or CL was tested against neuroblastoma PDXs. D GD2-BsAb and T cells were separately administered intravenously with or without intraperitoneal CL. In vivo anti-tumor effect of GD2-BsAb with CL was tested against M14 melanoma cell line xenografts and compared with control BsAb or GD2-BsAb without CL