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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state

Fig. 4

LIF is induced by KAI1 through Src/p53 axis in PCs. a Src phosphorylation levels and positions and Lif immunoblotting results in left, WT primary PC and Kai1−/− primary PC and, right, WT 10T1/2 and Kai1-O/E 10T1/2. b Quantification of the obtained results (ns not significant, *p < 0.01, **p < 0.05, Means ± SEM, 3 technical replicates). c Top, scheme, showing the regions targeted with the chromatin immune-precipitation (ChIP) assay and mutagenesis. Bottom, binding of p53 and Pbx1 on Lif gene-regulating element or promoter region using ChIP assay. d Activation of mouse Lif gene-regulating element or promoter in Kai1-O/E 10T1/2 cells using luciferase assay. ns not significant, *p < 0.01, **p < 0.05, ***p < 0.001

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