Fig. 13

The mechanism of AUTAC technology. The POI ligand in the AUTAC molecular composition is responsible for target specificity, while the degradation tag induces POI to trigger K63 polyubiquitination, which is then recognized by the autophagy receptor SQSTM1/p62 on the cell membrane to form autophagosomes, and finally, selective autophagy degradation is achieved in the lysosome. However, the specific mechanism by which degradation tags trigger K63 polyubiquitination is unclear