Fig. 2

An overview of AKT1/2/3 genes and proteins. a Human AKT1 gene has 15 exons, while AKT2 and AKT3 gene have 14 exons. b Akt protein has 3 domains, the plecstrin homology (PH) domain, kinase domain (KD) and C-terminal domain (CTD). The three conserved phosphorylation sites in Akt1, Akt2 and Akt3, and the kinases that phosphorylate these residues are shown