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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis

Fig. 4

Genes looped to metastasis-specific enhancers are associated with pancreatic cancer metastasis and poor prognosis. a Pie chart showing that genes looped to metastasis-specific enhancers enrich more upregulated genes. b Log2 (fold change) between Capan-1 and PANC-1 cells of genes that looped to primary-specific, common, and metastasis-specific enhancers (Wilcoxon rank-sum test, ****p < 0.0001). c Representative GO terms, which are associated with cancer metastasis, of significantly upregulated genes looped to metastasis-specific enhancers. d Kaplan–Meier survival analysis of 176 patients with pancreatic cancer from the TCGA PAAD dataset by calculating the gene set enrichment scores for the significantly upregulated genes in a. Whiskers of box plots are from Q1-1.5*IQR to Q3 + 1.5*IQR

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