Fig. 3

Metabolic consequences of STS-associated molecular alterations. This scheme integrates sarcoma genetic alterations affecting tumor suppressor genes (green background) or oncogenes (black background) in the tumor metabolic network. These alterations enhance enzymatic reactions in favor of anabolic pathways by increasing the glycolytic flux (pink) and branched pathways, notably nucleotide (yellow), fatty acids (orange) and DNA/RNA synthesis at the cost of dampens mitochondrial function and TCA cycle proper functioning