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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

Fig. 2

Schematics of MYC protein and its transcriptional activity. A: MYC gene on chromosome 8 alongside MYC protein (439 aa) that mainly contains the basic-region (BR), helix-loop-helix (HLH), and leucine-zipper (LZ) at C-terminal, and three extremely conserved regions called MYC boxes 1–3 (MB 1–3) at the N-terminal. B: The chromatin-modifying complex consisting of TIP60, TRRAP, TIP48, and GCN5 recruited by MYC/Max heterodimer propels transcription through binding to the E-box DNA region (CACGTG) within the regulatory domain of target genes. C: the accumulation of MYC at the promoter sequences of target genes increases the transcriptional activity. NLS nuclear localization sequence

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