Table 5 The PK profiles of navoximod
From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
Species | CL (mL/min/kg) | Cmax (ng/mL) | t1/2 (h) | F (%) | AUC (ng h/mL) |
|---|---|---|---|---|---|
Rat | 44.6 | 1560 | 1.44 | 41.5 | 3930 |
Mice | 27.5 | 2257 | 3.9 | 69.0 | 6132 |
Dog | 53.7 | 1400 | 4.8 | 22.3 | 3127 |