Table 1 Baseline characteristics by diagnosis period
Weeks 2–8 | Weeks 9–11 | Weeks 12–13 | Weeks 14–17 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
2018/2019a | 2020 | p | 2018/2019a | 2020 | p | 2018/2019a | 2020 | p | 2018/2019a | 2020 | p | |
Patients | 2547.5 | 2692 | 1074.5 | 995 | 737.5 | 436 | 1402 | 646 | ||||
Age | ||||||||||||
< 40 | 129.5 (5.1) | 142 (5.3) | 0.02 | 51 (4.8) | 44 (4.4) | 0.55 | 36.5 (5.0) | 19 (4.4) | 0.42 | 54 (3.9) | 64 (9.9) | < 0.01 |
40–49 | 389.5 (15.3) | 372 (13.8) | 158.5 (14.8) | 128 (12.9) | 104.5 (14.2) | 62 (14.2) | 204.5 (14.6) | 111 (17.2) | ||||
50–64 | 912.5 (35.8) | 898 (33.4) | 387.5 (36.1) | 368 (37.0) | 266.5 (36.1) | 175 (40.1) | 524.5 (37.4) | 200 (31.0) | ||||
65–74 | 674 (26.5) | 771 (28.6) | 284.5 (26.5) | 282 (28.3) | 206.5 (28.0) | 121 (27.8) | 358 (25.5) | 118 (18.3) | ||||
> 74 | 442 (17.4) | 509 (18.9) | 193 (18.0) | 173 (17.4) | 123.5 (16.8) | 59 (13.5) | 261 (18.6) | 153 (23.7) | ||||
SES | ||||||||||||
High | 782.5 (30.7) | 788 (29.3) | < 0.01 | 295.5 (27.5) | 316 (31.8) | 0.04 | 211.5 (28.7) | 133 (30.5) | 0.47 | 410.5 (29.3) | 206 (31.9) | 0.28 |
Medium | 992.5 (39.0) | 1169 (43.4) | 421 (39.2) | 379 (38.1) | 282.5 (38.3) | 153 (35.1) | 569.5 (40.6) | 242 (37.5) | ||||
Low | 763.5 (30.0) | 719 (26.7) | 355 (33.0) | 298 (30.0) | 239.5 (32.5) | 148 (33.9) | 413.5 (29.5) | 193 (29.9) | ||||
Unknown | 9 (0.4) | 16 (0.6) | 3 (0.3) | 2 (0.2) | 4 (0.5) | 2 (0.5) | 8.5 (0.6) | 5 (0.8) | ||||
Morphology | ||||||||||||
DCIS | 309 (12.1) | 352 (13.1) | 0.44 | 119.5 (11.1) | 125 (12.6) | 0.33 | 79.5 (10.8) | 65 (14.9) | 0.03 | 178 (12.7) | 42 (6.5) | 0.00 |
Invasive ductal | 1761.5 ( 69.2) | 1828 (67.9) | 756 (70.4) | 671 (67.4) | 504.5 (68.4) | 294 (67.4) | 951 (67.8) | 480 (74.3) | ||||
Invasive lobular | 342.5 (13.4) | 380 (14.1) | 135 (12.6) | 141 (14.2) | 122 (16.5) | 55 (12.6) | 198 (14.1) | 92 (14.2) | ||||
Other | 134.5 (5.3) | 132 (4.9) | 64 (6.0) | 58 (5.8) | 31.5 (4.3) | 22 (5.1) | 75 (5.4) | 32 (5.0) | ||||
Stage | ||||||||||||
DCIS | 309 (12.2) | 352 (13.2) | 0.25 | 119.5 (11.1) | 125 (12.6) | 0.69 | 79.5 (10.8) | 65 (15.0) | 0.09 | 178 (12.7) | 42 (6.6) | < 0.01 |
Stage I | 1044.5 (41.1) | 1075 (40.4) | 446 (41.6) | 418 (42.2) | 306 (41.6) | 167 (38.6) | 559.5 (40.0) | 212 (33.1) | ||||
Stage II | 828.5 (32.6) | 891 (33.5) | 358 (33.4) | 316 (31.9) | 247 (33.6) | 142 (32.8) | 473.5 (33.8) | 269 (42.0) | ||||
Stage III | 233.5 (9.2) | 211 (7.9) | 97 (9.0) | 82 (8.3) | 72 (9.8) | 35 (8.1) | 122 (8.7) | 64 (10.0) | ||||
Stage IV | 128 (5.0) | 134 (5.0) | 52 (4.9) | 49 (5.0) | 31 (4.2) | 24 (5.5) | 66.5 (4.8) | 54 (8.4) | ||||
Subtype | ||||||||||||
HR+/HER2+ | 210 (8.2) | 171 (6.4) | 0.01 | 74.5 (6.9) | 64 (6.4) | 0.88 | 48.5 (6.6) | 30 (6.9) | 0.59 | 111.5 (8.0) | 62 (9.6) | 0.12 |
HR+/HER2– | 1678 (65.9) | 1743 (64.8) | 717 (66.7) | 657 (66.0) | 510 (69.2) | 286 (65.6) | 921.5 (65.7) | 428 (66.3) | ||||
HR−/HER2+ | 83 (3.3) | 65 (2.4) | 41.5 (3.9) | 33 (3.3) | 30 (4.1) | 11 (2.5) | 42 (3.0) | 30 (4.6) | ||||
HR−/HER2− | 249 (9.8) | 275 (10.2) | 112 (10.4) | 98 (9.9) | 64.5 (8.8) | 35 (8.0) | 137.5 (9.8) | 76 (11.8) | ||||
Unknown | 327.5 (12.9) | 438 (16.3) | 129.5 (12.1) | 143 (14.4) | 84.5 (11.5) | 74 (17.0) | 189.5 (13.5) | 50 (7.7) | ||||
Region | ||||||||||||
North | 257.5 (10.1) | 254 (9.4) | 0.02 | 111.5 (10.4) | 99 (10.0) | 0.74 | 74 (10.0) | 46 (10.6) | 0.17 | 135 (9.6) | 71 (11.0) | 0.86 |
Middle East | 230.5 (9.1) | 257 (9.6) | 98.5 (9.2) | 97 (9.8) | 71.5 (9.7) | 55 (12.6) | 123.5 (8.8) | 59 (9.1) | ||||
Middle | 488 (19.2) | 589 (21.9) | 214 (19.9) | 208 (20.9) | 139 (18.9) | 94 (21.6) | 297.5 (21.2) | 132 (20.4) | ||||
West | 1010.5 (39.7) | 991 (36.8) | 406 (37.8) | 384 (38.6) | 304.5 (41.3) | 165 (37.8) | 538 (38.4) | 246 (38.1) | ||||
South | 560.5 (22.0) | 600 (22.3) | 244.5 (22.8) | 207 (20.8) | 148.5 (20.1) | 76 (17.4) | 308 (22.0) | 138 (21.4) | ||||
Screened | ||||||||||||
Yes | 810 (31.8) | 837 (31.1) | 0.87 | 354.5 (33.0) | 342 (34.4) | 0.43 | 256.5 (34.8) | 172 (39.5) | 0.12 | 455.5 (32.5) | 12 (1.9) | 0.00 |
No | 727.5 (28.6) | 762 (28.3) | 299 (27.8) | 275 (27.6) | 201.5 (27.3) | 107 (24.5) | 403.5 (28.8) | 282 (43.7) | ||||
Not eligible | 961 (37.7) | 1023 (38.0) | 402.5 (37.5) | 345 (34.7) | 264.5 (35.9) | 140 (32.1) | 519.5 (37.1) | 328 (50.8) | ||||
Unknown | 49 (1.9) | 70 (2.6) | 18.5 (1.7) | 33 (3.3) | 15 (2.0) | 17 (3.9) | 23.5 (1.7) | 24 (3.7) | ||||