Fig. 3From: Targeting neddylation E2s: a novel therapeutic strategy in cancerCross-talk between the E2 and E3 [89]. UBE2M, a stress-inducible protein promoted by HIF-1α and AP-1, plays a dual role as an E2 for ubiquitylation and neddylation to degrade the UBE2F, leading to the inactivation of CRL5 mediated by CRL3Back to article page