Table 1 Baseline patient, donor and disease characteristics at diagnosis
Clinical parameter | MSD (n = 1891) | Haplo (n = 413) | p |
|---|---|---|---|
Follow-up duration in m, median (range) | 24.88 (12.13;46.05) | 25.37 (13.21;42.56) | 0.92 |
Age at transplant in years, median (range) | 37.7 (18–76.1) [27–49.5] | 37.1 (18.1–75) [25.7–51] | 0.58 |
Year of transplant | 2015 (2012–2018) | 2016 (2012–2018) | < 0.0001 |
Patient gender, n (%) | Â | Â | Â |
Male | 1129 (59.8%) | 268 (64.9%) | 0.055 |
Female | 759 (40.2%) | 145 (35.1%) | Â |
Diagnosis | Â | Â | Â |
Ph-neg B ALL | 616 (32.6%) | 148 (35.8%) | 0.44 |
Ph-pos B ALL | 725 (38.3%) | 151 (36.6%) | Â |
T-ALL | 550 (29.1%) | 114 (27.6%) | Â |
Patient CMV status | Â | Â | Â |
Patient CMV negative, n (%) | 521 (28.1%) | 90 (22%) | 0.01 |
Patient CMV positive, n (%) | 1335 (71.9%) | 319 (78%) | Â |
Donor CMV status | Â | Â | Â |
Donor CMV negative, n (%) | 599 (33%) | 110 (27.1%) | 0.021 |
Donor CMV positive, n (%) | 1215 (67%) | 296 (72.9%) | Â |
Status at transplant | Â | Â | Â |
CR1 | 1575 (83.3%) | 275 (66.6%) | < 0.0001 |
CR2 | 316 (16.7%) | 138 (33.4%) | Â |
KPS at transplant, n (%) | Â | Â | Â |
< 90 | 397 (22.4%) | 100 (25%) | 0.27 |
≥ 90 | 1373 (77.6%) | 300 (75%) |  |
Missing | 121 | 13 | Â |
Donor age, y median (range) | 38.5 (0.1–74) [27.5–50.5] | 38.8 (7.8–74.3) [27.1–49.3] | 0.79 |
Donor gender | Â | Â | Â |
Male donor | 1033 (54.9%) | 242 (58.6%) | 0.17 |
Female donor | 848 (45.1%) | 171 (41.4%) | Â |
Donor-recipient gender matching, n (%) | Â | Â | Â |
Female–male | 474 (25.2%) | 110 (26.6%) | 0.54 |
Other | 1408 (74.8%) | 303 (73.4%) | Â |
MRD at transplant | Â | Â | Â |
Negative | 681 (67.4%) | 162 (65.3%) | 0.54 |
Positive | 330 (32.6%) | 86 (34.7%) | Â |
Missing | 880 | 165 | Â |