From: Targeting chemokines for acute lymphoblastic leukemia therapy
 | Pathways | Roles | References |
---|---|---|---|
CXCL12/CXCR4 | Myc | Proliferation | [16] |
Src and ABL1/RhoGDI2/RhoA and RhoC | Migration | ||
P38MAPK | Migration, homing | ||
RAC1 | Migration | ||
ERK1/2 | Infiltration, survival | [55] | |
PI3K/Akt | Survival | [60] | |
CCL25/CCR9 | RhoA-Rock-MLC and ezrin | Infiltration | |
PI3K/Akt-RhoA | Infiltration | [71] | |
P-gp/ERM/F-actin | Drug resistance | [75] | |
CXCL10/CXCR3 | Bcl-2/caspases | Survival | [80] |
MMP9 | Invasion | [82] | |
CCR5 | JAK/STAT3 | Proliferation, migration | [94] |