Table 1 Hypoxia-related noncoding RNAs in pancreatic cancer

lncRNA

NORAD

Up

NORAD—miR-125a-3p—RhoA

Promotes EMT and metastasis

[165]

FEZF1-AS1

Up

FEZF1-AS1—miR-142—HIF-1α

Promotes cell proliferation and invasion ability

[167]

MTA2TR

Up

MTA2TR—ATF3—MTA2—HIF-1α loop

Promotes cell proliferation and invasion

[174]

BX111

Up

HIF-1α—YB1—ZEB1—E-cadherin, MMP2

Promotes growth and metastasis

[175]

NUTF2P3-001

Up

NUTF2P3-001—miR-3923—KRAS

Promotes the proliferation and invasion

[176]

CF129

Down

HIF-1α—CF129—p53—FOXC2 loop

Inhibits cell proliferation, invasion, and metastasis

[177]

miRNA

circ_0000977

Up

circ_0000977—miR-153—HIF-1α, ADAM10

Promotes immune escape

[178]

miR-191

Up

HIF-1α—miR-191

Promotes tumorigenesis

[179]

miR-21

Up

miR-21—HIF-1α—VEGF, MMP2, MMP9

Promotes cell proliferation, migration, and invasion

[180]

HIF-1α—miR-21

Avoids apoptosis

[181]

miR-210

Up

miR-210—HOXA9—NF-κB

Promotes EMT

[132]

miR-212

Up

HIF-1α—miR-212

Promotes progression

[182]

miR-224

Up

miR-224—TXNIP—HIF-1α

Promotes cell proliferation and migration

[168]

miR-301a

Up

HIF-2α—miR-301a—TP63

Promotes EMT

[166]

miR-301a—TAp63

[173]

miR-301a-3p

Up

miR-301a-3p—PTEN/PI3K—M2 macrophages polarization

Promotes metastasis

[169]

miR-646

Up

HIF-1α—miR-646—MIIP—HDAC6 loop

Promotes proliferation and invasion

[183]

miR-124

Down

miR-124—MCT1—HIF-1α—LDHA

Increases intracellular pH, inhibits glycolytic activity and tumor growth

[53]

miR-125a

Down

miR-125a—Mfn2—mitochondrial fission

Impairs cell migration capacity

[170]

miR-138-5p

Down

miR-138-5p—SIRT1—FOXO1—Rab7

Inhibits autophagy and tumor growth

[104]

miR-142

Down

miR-142—HIF-1α—vimentin, VEGF-C, E-cadherin

Inhibits proliferation, EMT, and invasion

[184]

miR-150

Down

miRNA-150—CXCR4

Inhibits migration and invasion

[185]

miR-519

Down

miR-519—PD-L1

Inhibits cell invasiveness, and induces apoptosis

[186]

miR-548an

Down

HIF-1α—HDAC1—miR-548an—vimentin

Inhibits the proliferation and invasion

[187]