Fig. 1

High-frequency BRCA1/2 pathogenic variants distribution in Europe and USA, Asia*, and our study. Europe and USA: Include Ashkenazi Jew, Icelander, Norwegian, Finns, Swede, French, Dutch, Italian, French-Canadian, Hispanics (South California), Hispanics (Columbia), Afro-American, South African; Asia*: Include Iraqi/Iranian Jew, Singaporean, Filipino, Pakistani, Japanese, and Korean. a High-frequency BRCA1 pathogenic variants distribution in Europe and USA, Asia*and China. Domains are Zinc/Ring finger (green); Serine cluster domain (blue); BRCT domain (red); BRCT (C terminus) (yellow). Variants in different region are indicated by color: blue: Europe and USA; green: Asia*; red: our study. One dot represents one variant; gray line length represents the number of groups with the variant. b High-frequency BRCA2 pathogenic variants distribution in Europe and USA, Asia*and China. Domains are BRCA repeats (green); BRCA helica (red); OB binding domain (blue); tower (yellow) and OB3 binding domain (purple). Variants in different region are indicated by color: blue: Europe and USA; green: Asia*; red: our study. One dot represents one variant; gray line length represents the number of groups with the variant