From: Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer
Regulators | Effectors | Targets | Cancer type | Biological process | Reference |
---|---|---|---|---|---|
miR-233 | HSP70 | HSPA1A | Osteosarcoma | Regulates apoptosis | [25] |
miR-216b | CHOP | c-JUN | Osteosarcoma | Sensitizes cells to apoptosis | [79] |
miR-30c-2* | XBP1 | XBP1 | Cervical cancer | Influences the fate of cells challenged with ER stress | [80] |
miR-657 | CHOP | NA | Hematological cancer | Attenuates the expression of CHOP, p-ATF2, and PARP cleavage to reverse SSD-induced apoptosis | [91] |
miR-211 | CHOP | NA | Lymphoma, multiple myeloma | Attenuates COM-induced apoptosis | [92] |
miR-34c | eIF2α CHOP IRE1α | HMGB1 | NSCLC | Inhibits cell proliferation, promotes apoptosis, and induces ER stress in NSCLC cells | [93] |
miR-451a | GRP78 PERK elF2α ATF4 CHOP | BAP31 | Colorectal cancer | Inhibits proliferation and increases apoptosis | [98] |
miR-410 | CHOP GRP94 GRP78 eIF2α | ERLIN2 | Breast cancer | Inhibits cell migration and invasion and EMT | [108] |
miR-224 miR-520c | ATF6α | TUSC3 | NSCLC | Enhances UPR and ERAD to promote metastatic potential of | [109] |
miR-122 | GRP78 CHOP | CDK4 | HCC | Regulates anticancer drug–mediated apoptosis | [167] |
miR-146a | CHOP | CHOP | Lung cancer | Reduces the sensitivity of lung cancer cells to cisplatin | [171] |
miR-7112-3p | PERK | PERK | Colorectal cancer | Enhances apoptosis in CX-1 cells treated with DVDMS-PDT | [174] |
miR-1202 | GRP78 | Rab1A | Glioma | Inhibits proliferation and induces ER stress and apoptosis | [187] |
miR-15b-5p | GRP78 | Rab1A | HCC | Induces apoptosis | [188] |
miR-1291 | IRE1α | IRE1α | HCC | Regulates glypican-3 mRNA expression | [189] |
miR-30d miR-181a miR-199a-5p | GRP78 | GRP78 | Prostate cancer | Suppresses GRP78 levels and GRP78-mediated chemoresistance | [190] |