Fig. 2From: Molecular and cellular mechanisms of aging in hematopoietic stem cells and their nichesAging-related changes in fHSCs. Single-cell transplantation studies demonstrate a 2–3-fold expansion of Bala-HSCs, suggesting that functionally normal HSCs exist in aged mice. A significant number of latent HSCs can be detected only in elderly. In addition, more defective HSCs and NR-HSCs can be detected in older miceBack to article page