Fig. 1
From: Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia
Schematics illustrating a monomeric FLT3. Glycosylated FLT3 is anchored on the plasma membrane (PM) with the transmembrane domain (TM), and its immunoglobulin-like ligand binding domain protrudes out to the extracellular domain (ECD). In the cytoplasm (CP), the juxtamembrane domain (JM) extends and connects with the two kinase domain lobes (TK1 and TK2) that are linked by the activation loop (AL)