Table 2 Proteins on exosomes as biomarkers in cancer
From: Isolation and characterization of exosomes for cancer research
Cancer | Proteins | Samples | Biological effects | Refs. |
|---|---|---|---|---|
Pancreatic cancer | Glypican-1 CKAP4 Eps8 ZIP4 | Serum Serum Serum Serum | Unknown Promoting cells proliferation and migration Promoting tumor metastasis Promoting tumor growth | [200] [213] [214] [215] |
Colorectal cancer | CPNE3 TMEM180 | Plasma Supernatant | Unknown Uptaking or metabolizing glutamine and arginine | [216] [217] |
Breast cancer | AnxA2 CD82 HSP70 MTA1 TRPC5 | Serum Serum/Plasma Blood Serum Blood | Promoting angiogenesis Inhibiting tumor cells metastasis Promoting tumor progression Promoting tumor progression Promoting tumor chemoresistance | [218] [219] [220] [221] [222] |
Glioblastoma | PTRF | Serum | Altering tumor microenvironment | [223] |
Gastric cancer | GKN1 | Serum | Maintaining mucosal homeostasis and regulating cell proliferation and differentiation | [224] |
PSMA3 | Serum | Promoting tumor metastasis | [225] | |
PSMA6 | Serum | Promoting tumor metastasis | [225] | |
TRIM3 | Serum | Inhibiting tumor growth and metastasis | [226] | |
Prostate cancer | EphrinA2 αvβ3 | Serum Blood | Regulating tumor invasiveness and tumorigenesis Promoting tumor cell migration | [227] [228] |
Lung cancer | ADAM10 | Blood | Mediating tumor progression | [229] |