Adults [38] | Children [39] |
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Classical (first 21 days after HSCT) Bilirubin ≥ 2 mg/dL and 2 of the following criteria must be present: • Painful hepatomegaly • Weight gain > 5% • Ascites Late onset (> 21 days after HSCT) Classical VOD/SOS beyond day 21 OR Histologically proven SOS/VOD OR ≥ 2 of the following criteria must be present: • Bilirubin ≥ 2 mg/dL (or 34 μmol/L) • Painful hepatomegaly • Weight gain > 5% • Ascites AND hemodynamical and/or ultrasound evidence of SOS/VOD | No limitation for time of onset of SOS/VOD The presence of ≥ 2 of the following:a • Unexplained consumptive and transfusion-refractory thrombocytopeniab • Otherwise unexplained weight gain on 3 consecutive days despite the use of diuretics or a weight gain > 5% above baseline value • Hepatomegalyc (best if confirmed by imaging) above baseline value • Ascitesc (best if confirmed by imaging) above baseline value • Rising bilirubin from a baseline value on 3 consecutive days or bilirubin ≥ 2 mg/dL within 72 h |