Term | All grades | Grade 3 | Grade 4 |
---|---|---|---|
n (%) | |||
Patients with at least 1 adverse event | 91 (100) | 58 (63.7) | 8 (8.8) |
Hematologic events | |||
Neutropeniaa | 63 (69.2) | 34 (37.4) | 6 (6.6) |
Thrombocytopeniab | 38 (41.8) | 13 (14.3) | 1 (1.1) |
Anemiac | 27 (29.7) | 8 (8.8) | 0 |
Leukopeniad | 19 (20.9) | 6 (6.6) | 0 |
Nonhematologic events | |||
Upper respiratory tract infection | 41 (45.1) | 9 (9.9) | 0 |
Hematuria/blood urine present | 36 (39.6) | 0 | 0 |
Petechiae, purpura, or contusion | 32 (35.2) | 0 | 0 |
Hypokalemia | 23 (25.3) | 6 (6.6) | 0 |
Cough | 22 (24.2) | 1 (1.1) | 0 |
Carbon dioxide increased | 19 (20.9) | 0 | 0 |
Hyperglycemia | 19 (20.9) | 2 (2.2) | 0 |
Diarrhea | 18 (19.8) | 2 (2.2) | 0 |
Lung infection/pneumonia | 20 (22.0) | 11 (12.1) | 0e |
Urinary tract infection | 15 (16.5) | 1 (1.1) | 0 |
Rash | 13 (14.3) | 0 | 0 |
Urobilinogen increased | 12 (13.2) | 0 | 0 |
Alanine amino transferase increased | 11 (12.1) | 1 (1.1) | 0 |
Hypoalbuminemia | 11 (12.1) | 1 (1.1) | 0 |
Aspartate amino transferase increased | 10 (11.0) | 1 (1.1) | 0 |
Hyperuricemia | 10 (11.0) | 1 (1.1) | 1 (1.1) |
Pyrexia | 10 (11.0) | 0 | 0 |
Hyponatremia | 9 (9.9) | 4 (4.4) | 0 |
Hypocalcemia | 9 (9.9) | 2 (2.2) | 0 |
Hypertensionf | 9 (9.9) | 2 (2.2) | 0 |
Skin infection | 8 (8.8) | 2 (2.2) | 0 |
Bronchitis | 6 (6.6) | 2 (2.2) | 0 |
Gastroenteritis | 5 (5.5) | 2 (2.2) | 0 |
Hepatitis B reactivation | 3 (3.3) | 2 (2.2) | 0 |
Infectious enteritis | 2 (2.2) | 2 (2.2) | 0 |