Fig. 2
From: Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
Inhibitor-induced differential gene expression and anti-proliferative effects in AML/ALL cells. a IC50 (μM) values of BAY-155, OTX015, EPZ-5676, BAY 1251152, and Brequinar after 1, 4, and 7 days of treatment. In the case where IC50 determination was beyond tested maximal concentration (10 μM), > 10 μM is used. ALL cell lines are indicated by gray name box shading. b Number of genes upregulated (red bars) and downregulated (blue bars) upon treatment by the indicated inhibitors in non-fused MLL-WT (left from the dashed line) and MLL-fused (right from the dashed line) models (log2FC > 1, FDR < 0.1). pIC50 (− log10 (IC50) in M) values (diamond shape) for the indicated inhibitors and cell models after 4 days of treatment. In the situation where pIC50 determination was beyond maximal concentration, no data point is shown. c Correlation of differential gene expression effects between inhibitors and cell models. Heatmap represents correlation of log2FC of gene expression grouped based on the inhibitor in all used cell lines ordered identically to b. Black boxes indicate cell line comparison for a single inhibitor