Fig. 1

CD73 is downregulated on CD8 T cells in patients with newly diagnosed AML compared with healthy controls and patients with complete remission (CR). Flow cytometry analysis of CD73 expression was performed on PBMCs collected from AML patients at the initial diagnosis (n = 27), healthy donors (n = 16), and CR patients (n = 6). a, b The expression of CD73 on leukemic blasts, T cells (CD4, CD8 T cells, and Treg), natural killer cells, and myeloid cells (monocytes and dendritic cells) was assessed by flow cytometry. Representative flow data (a) and summary plot (b) of CD73 expression on indicated subsets were shown; each dot indicates one patient. P values were obtained by the unpaired t test or Mann-Whitney test. ***P < 0.001. c Representative histogram (left) and summary plot (right) of CD73 expression on CD8 T cells from healthy donors vs. AML patients. P values were obtained by unpaired t test. d Representative flow data (left) and plots (right) showing expression of CD73 on CD8 T cells from AML patients at initial diagnosis and complete remission. P values were obtained by paired t test