Table 2 Univariate and multivariate analyses of factors associated with OS and recurrence rate
Variable | OS | Recurrence | ||||||
|---|---|---|---|---|---|---|---|---|
Multivariate analysis | Multivariate analysis | |||||||
Univariate p | HR | 95%CI | p* | Univariate p | HR | 95%CI | p | |
Age, years (≥ 60 vs. <60) | 0.226 | NA | 0.281 | NA | ||||
Gender (men vs. women) | 0.735 | NA | 0.787 | NA | ||||
Anatomic site (acra vs. trunk vs. other) | 0.867 | NA | 0.892 | NA | ||||
Histologic type (superficial spreading vs. nodular vs. acral vs. Lentigo maligna) | 0.095 | NA | 0.076 | NA | ||||
Ulceration (present vs. absent) | 0.267 | NA | 0.245 | NA | ||||
Breslow depth(mm) (≤ 2 vs. > 2) | 0.018* | NS | 0.016* | NS | ||||
Clark level (I–III vs. IV–V) | 0.015* | 1.629 | 1.102-2.347 | 0.011 | 0.025 | 1.534 | 1.012–2.316 | 0.018 |
Lymph nodes metastasis (yes vs. no) | 0.016* | NS | 0.014* | NS | ||||
Distant metastasis (yes vs. no) | 0.002* | NS | 0.002* | NS | ||||
Clinical stage (yes vs. no) | < 0.001 | 3.936 | 2.365–6.521 | < 0.001 | < 0.001 | 3.998 | 2.447–6.607 | < 0.001 |
RNF128 staining (low vs. high) | 0.004 | 1.724 | 1.237–2.587 | 0.026 | 0.008 | 1.753 | 1.154–2.508 | 0.039 |