Skip to main content
Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer

Fig. 7

SNHG6 regulates expression of the common target of miR-214, miR-26a, or miR-26b, EZH2. a, b EZH2 expression was detected by qRT-PCR or western blotting in HCT-116 cells with indicated treatment. SNHG6-mt contains mutations at the putative miR-214-3p, miR-26a-5p, and miR-26b-5p binding sites. c Luciferase activity of Luc-EZH2 reporters which contained the 3′-untranslated region (3′-UTR) of EZH2 with indicated treatment in HCT-116 cells. d RIP assay of the enrichment of Ago2 on SNHG6 and EZH2 transcripts relative to IgG in HCT-116 cells transfected with SNHG6 overexpression vectors or siRNAs. e Results of GSEA were plotted to visualize the correlation between the expression of SNHG6 and genes related with EZH2 targets (KONDO_EZH2 _TARGETS). Scale bar = 50 μm. *P < 0.05, **P < 0.01, and ***P < 0.001

Back to article page