Fig. 5

a Evaluation by quantitative real-time PCR of mRNA expression of TRAP, CTSK and MMP9 in Raw 264.7 cells incubated with exosomes from MM patients (50 μg/ml) treated or not with anti-AREG mAb (50 μg/ml). b MMP9 protein level was measured in the conditioned medium of Raw 264.7 cells incubated, for 6 days, with exosomes from MM patients (50 μg/ml) treated or not with anti-AREG mAb (50 μg/ml), rhRANKL (25 μg/ml), and rhAREG (50 μg/ml). *Exo vs untreated (*p ≤ 0.05; **p ≤ 0.01); ^#Exo+AREG mAb vs Exo (^#p ≤ 0.05; ^##p ≤ 0.01)