Fig. 4

a MM patient exosomes size distribution was determined by DLS analysis. b Total proteins were extracted from exosomes isolated from the BM plasma of MM patients and were subjected to western blot analysis with antibody against AREG and Tsg101. The table below indicates the clinical information of the four MM patients analyzed. c Evaluation by quantitative real-time PCR of mRNA expression of SNAIL in Raw 264.7 cells incubated with exosomes from MM patients (50 μg/ml) treated or not with anti-AREG mAb (50 μg/ml). *Exo vs untreated (**p ≤ 0.01); ^#Exo+AREG mAb vs Exo (^##p ≤ 0.01)