Fig. 4

Comparative analysis of lipid metabolism between 7 tumors with relapse and 45 tumors without relapse. a The IPA disease/function analysis confirmed that gene level alterations corresponded to lipid metabolism. The calculated z-score indicates a bio-function with genes exhibiting overall increased mRNA levels (orange bars) or decreased mRNA levels (blue bars). The most significantly altered bio-function bars are highlighted with a green border. b Upstream regulator analysis of PPARγ in lipid metabolism. Upregulated genes are highlighted in red and color depth is correlated with fold change. Orange lines with arrows indicate direct activation. Solid and dashed lines represent direct and indirect interactions, respectively. Yellow and gray lines depict inconsistent effects and no prediction, respectively. c Heatmap summarizing the changes in lipid metabolism-related gene expression in tumors with and without relapse. Red and blue represent relative high and low log2 gene expression values, respectively. NE not evaluated