Table 3 Transplant-related events multivariate analysis
Outcome | Hazard ratio (95% confidence interval) | p value |
|---|---|---|
Overall survival | ||
ATG versus CD34 | 1.43 (0.97–2.11) | 0.07 |
Age per 10 years | 1.15 (1.00–1.34) | 0.047 |
Poor versus intermediate cytogenetic | 1.16 (1.11–2.19) | 0.009 |
Unrelated versus related donor | 1.23 (0.86–1.76) | 0.27 |
Leukemia-free survival | ||
ATG versus CD34 | 1.25 (0.88–1.78) | 0.21 |
Age per 10 years | 1.03 (0.91–1.17) | 0.60 |
Poor versus intermediate cytogenetic | 1.70 (1.26–2.31) | 0.0006 |
Unrelated versus related donor | 1.22 (0.88–1.70) | 0.23 |
Non-relapse mortality | ||
ATG versus CD34 | 0.96 (0.54–1.74) | 0.90 |
Age per 10 years | 1.32 (1.03–1.68) | 0.02 |
Poor versus intermediate cytogenetic | 1.08 (0.62–1.90) | 0.77 |
Unrelated versus related donor | 1.39 (0.8–2.42) | 0.24 |
Relapse | ||
ATG versus CD34 | 1.52 (0.96–2.42) | 0.07 |
Age per 10 years | 0.93 (0.80–1.08) | 0.31 |
Poor versus intermediate cytogenetic | 2.10 (1.46–3.03) | < 0.0001 |
Unrelated versus related donor | 1.10 (0.73–1.67) | 0.63 |
Grade II-IV acute GVHD | ||
ATG versus CD34 | 2.05 (1.12–3.73) | 0.02 |
Age per 10 years | 0.99 (0.82–1.18) | 0.87 |
Poor versus intermediate cytogenetic | 0.90 (0.56–1.48) | 0.66 |
Unrelated versus related donor | 1.87 (1.12–3.09) | 0.02 |
Chronic GVHD | ||
ATG versus CD34 | 15.07 (5.38–42.26) | < 0.0001 |
Age per 10 years | 1.13 (0.94–1.36) | 0.21 |
Poor versus intermediate cytogenetic | 1.07 (0.66–1.74) | 0.79 |
Unrelated versus related donor | 1.58 (0.97–2.56) | 0.07 |
GVHD-free relapse-free survival | ||
ATG versus CD34 | 1.60 (1.14–2.34) | 0.006 |
Age per 10 years | 1.01 (0.90–1.13) | 0.88 |
Poor versus intermediate cytogenetic | 1.65 (1.25–2.18) | 0.0004 |
Unrelated versus related donor | 1.42 (1.05–1.93) | 0.02 |