Fig. 2

Targets and pathways of HDAC6. (A) HDAC6 binds to cortactin and induces its deacetylation, thereby activating the small GTPase Rac1 and actin-nucleated complex Arp2/3. Therefore, cortactin can be easily transferred to the cell edge and bind with F-actin to stimulate cell movement. (B) Under high levels of HDAC6, STAT3 is accumulated in its phosphorylation state, which reduces the interaction of STAT3 and PP2A. After entering into the nucleus, pSTAT3 and HDAC6 together bind the PD-L1 promoter to promote the expression of PD-L1. (C) In response to the high expression of HDAC6, the acetylation of MTs is decreased, and the interaction of CYLD and BCL3 is increased. CYLD is translocated to the cell periphery to bind acetylated microtubules, which allows BCL3 to enter into the nucleus, thereby promoting the expression of cyclin D1