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Table 2 LncRNAs and miRNAs involved in regulating tumor metabolism

From: Emerging roles of long non-coding RNAs in tumor metabolism

Gene Target Signaling Potential functions and indication Ref.
lncRNA and glucose metabolism
 ANRIL GLUT1 and LDHA PI3/AKT/mTOR Increase glucose uptake, prognosis [33, 40]
 NBR2 GLUT1 LKB1/AMPK Decrease glucose uptake, increases autophagy, prognosis [34]
 CRNDE GLUT4 PI3/AKT/mTOR Increases glucose uptake [30, 136]
 GCASPC miR-17-3P HIF1/MYC Decrease pyruvate carboxylase, prognosis [48]
 NRCP STAT1 Not mentioned Increase glycolysis, prognosis [49]
 PVT1 HK2 miR-497/HK2 axis Increase glucose metabolism, prognosis [60]
 H19 let-7 HIF1/MYC Increase insulin sensitivity, enhance glucose tolerance, prognosis [62]
 MALAT1   HIF1/MYC Increase glycolysis [146]
microRNA and glucose metabolism
 miR-195-5p GLUT3 LKB1/AMPK Decrease glucose uptake [148]
 miR-210 GPD1L HIF1/MYC Decrease glycolysis, prognosis [149, 150]
 miR-223 c-MYC HIF1/MYC Increase glucose uptake, prognosis [151]
 miR-143 HK2 PI3K/AKT/mTOR Decrease glucose metabolism [147]
 miR-21 PTEN PI3K/AKT/mTOR Increase glucose metabolism, prognosis [152]
 miR-326 PKM2 LKB1/AMPK Decrease glycolysis [153]
 miR-451 CAB39 LKB1/AMPK Increase glucose metabolism, prognosis [156]
 miR-29 MCT1 P53, PI3K/AKT/mTOR Caused insulin resistance, prognosis [154, 155]
LncRNA and lipid metabolism
 LncHR1 SREBP-1c and FAS PI3K/AKT/mTOR Decrease lipid metabolism [69]
 LNMICC miR-190 miR-190/LNMICC/FABP5 axis Increase fatty acid metabolism, prognosis [71]
 SRA Not mentioned AKT/FOXO1 axis Decrease adipogenesis and glucose uptake [77]
 HULC miR-9 miR-9/PPARγ/ACSL1 axis Increase the deregulation of lipid metabolism [76]
miRNA and lipid metabolism
 miR-122 CyclinB1 P53 Increase cholesterol synthesis and lipogenesis [157]
lncRNA and glutamine metabolism
 TUG1 miR-145 Sirt3/GDH axis Increase glutamine metabolism, prognosis [81]
 UCA1 miR-16 PI3/AKT/mTOR Increase glutamine metabolism [160]
 miRNA and glutamine metabolism
 miR-23b c-MYC HIF1/MYC Increase the biosynthesis of proline from glutamine [161]