From: Abscopal effect of radiotherapy combined with immune checkpoint inhibitors
Effect of RT | Pro-immunogenic | Anti-immunogenic |
---|---|---|
Cytokine secretion | IFN I | TGF-β |
IFN II | CSF-1 | |
IL-1β | IL-6 | |
IL-18 | IL-10 | |
Chemokine secretion | CXCL9 | CXCL12 |
 | CXCL10 |  |
 | CXCL16 |  |
Leukocyte infiltration | DCs | MDSCs |
Effector T cells | Treg cells | |
M1 macrophages | M2 macrophages | |
Signal molecule expression | MHC-I | PD-L1 |
STING | Trex 1 | |
Fas | Â |