Table 2 Target mRNAs of IGF2BP1

eEF2

Increasing basal protein translation rates

Enhancing basal proliferation rates

[102]

CD44

3′-UTR

Stabilization of the transcript

Involving in invadopodia formation, cell migration, tumor growth and progression.

[83]

c-Myc

CDS

Inhibition of CRD-dependent mRNA decay

Promoting the tumor cell proliferation

[40]

ACTB

3′-UTR

Inhibition of mRNA translation;

Involving in various types of cell motility

[101]

IGF2

5′-UTR

Inhibition of mRNA translation

Promoting cell growth and proliferation

[8]

PTEN

CDS

Inhibition of CRD-dependent mRNA decay

Modulation of actin dynamics and cell migration; modulating cell cycle progression and cell survival; promoting cell polarization and directed movement.

[100]

MDR1

CDS

Inhibition of CRD-dependent mRNA decay

NA

[8]

MAPK4

3′-UTR

Inhibition of mRNA translation

Modulating actin dynamics and cell migration; promoting entry in the cell cycle

[100]

PPP1R9B

3′-UTR

mRNA transport

Involving in linking the actin cytoskeleton to the plasma membrane at the synaptic junction

[8]

BTRC

CDS

Inhibition of betaTrCP1 mRNA degradation

Mediating the ubiquitination and subsequent proteasomal degradation of target proteins

[102]

CTNNB1

3′-UTR

Inhibition of mRNA decay

Regulating cell adhesion; promoting neurogenesis

[8]

KRAS

CDS, 3′-UTR

Inhibition of mRNA decay

Modulating cell proliferation; promoting oncogenic events

[66, 67]

PABPC1

5′-UTR

mRNA translation

Regulating mRNA metabolism, and translationally coupled mRNA turnover

[29]

H19

3′-UTR

mRNA localization

Involving in migration and invasion

[29]

GLI1

CDS

Inhibition of mRNA decay

Regulating cell proliferation and differentiation; promoting cancer cell migration

[29]

cIAP1

5′-UTR IRES

Enhancing IRES-mediated translation

Modulating cell proliferation, as well as cell invasion and metastasis, and cell cycle

[77)

RAPGEF2

Inhibiting cell proliferation of melanoma cells and promotes their apoptosis; regulating embryonic blood vessel formation; establishment of basal junction integrity and endothelial barrier function

[100]

RPS6KA5

Involving in neuronal cell death; limiting the production of pro-inflammatory cytokines

[100]

RSK2

Stabilization of the transcript

Promoting cell migration and invasion

[99]

PPME1

Stabilization of the transcript

Promoting cell migration and invasion

[99]

ITGA6

NA

NA

Mediating cell adhesion to extra cellular matrix or to other cells, and fertilization of ova and embryonic development

[28]

ETV6/RUNX1 mRNA (potential)

Stability of this transcript

NA

[97]

GDF15

3′-UTR

Inhibition of this transcript

Inhibiting breast cancer cell migration and invasion

[17]

RGS4

Inhibiting signal transduction and breast cancer cell migration and invasion

[17]

PTGS2

Modulating production of inflammatory prostaglandins, and motility, proliferation, and resistance to apoptosis.

[17]

CDH1

Localization of the mRNAs

Regulating cell–cell adhesions, mobility, and proliferation of epithelial cells; downregulation of cell growth

[53]

β-actin

Localization of the mRNAs

Involving in establishment of cell polarity and cell motility

[53]

α-actinin

Localization of the mRNAs

Regulating focal adhesion metabolism

[53]

Arp2/3

Localization of the mRNAs

Regulating focal adhesion metabolism, actin polymerization, and the formation of branched actin networks

[53]

TAU

3′-UTR

Localization of the mRNAs

Promoting microtubule assembly and stability; establishment and maintenance of neuronal polarity

[53]

MKI67

Stability of this transcript

Promoting the tumor cell proliferation

[40]