Fig. 2
From: Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties
HepG2 exosomes change the transcriptome of adipocytes and induce production of inflammatory cytokines. a The scatter plot assessed the gene expression variations between exosome-treated adipocytes and control. The red dots indicate upregulated genes and green dots downregulated genes. b The top 10 up- and downregulated genes in HepG2 exosome-treated adipocytes compared to control (E represents exosome-treated adipocytes, C represents control). c Unsupervised hierarchical clustering based on the expression of genes associated with inflammation. d Enhanced release of IL-6, IL-8, and MCP-1 was detected by qRT-PCR (left) and ELISA (right) (*P < 0.05, **P < 0.01, ***P < 0.001). e A partial dose-dependent effect of exosomes on the secretion of IL-6, IL-8, and MCP-1 (*P < 0.05, **P < 0.01, ***P < 0.001)