Fig. 1
LINC00470 positively regulated the pAKT level. a Left, a heat map of LINC00470 correlated gene-expression signatures and the functional enrichment analysis of associated genes; right, enriched canonical pathways of the differentially expressed genes using Ingenuity Pathway Analysis (IPA). b Western blotting detected the expression levels of AKT, p-AKTT308, and p-AKTS473 in GBM cells by transfected them with pcDNA3.1- LINC00470. c Western blotting evaluated the expression levels of AKT, p-AKTT308, and p-AKTS473 in si-LINC00470-transfected GBM cells. d Upper, RT-qPCR measured the expression of LINC00470 in the LINC00470-KD GBM cell lines by re-expressing LINC00470; lower, Western blotting evaluated the expression levels of p-AKTT308 and p-AKTS473 and AKT in the LINC00470-KD GBM cells by re-expressing LINC00470. Data are presented as the mean ± S.E.M. of three independent experiments; **p < 0.01, ***p < 0.001