Table 1 Demographics comparison of 438 patients with or without MET alterations
Characteristics | Total patients, N = 438 (100%) | MET wild type, N = 407 (92.9%) | MET alteration(s), N = 31 (7.1%) | P values* |
|---|---|---|---|---|
Age at diagnosis (years) (median, CI 95%) | 57.5 (54.5–59.1) | 57.7 (55.3–59.2) | 53.8 (49.0–62.2) | 0.791 |
Gender | 0.288 | |||
Women | 228 (52.1%) | 209 (91.7%) | 19 (8.3%) | |
Men | 210 (47.9%) | 198 (94.3%) | 12 (5.7%) | |
Ethnicity | ||||
Caucasian | 303 (69.2%) | 284 (93.7%) | 19 (6.3%) | 0.326 |
Asian | 52 (11.9%) | 46 (88.5%) | 6 (11.5%) | 0.188 |
Hispanic | 30 (6.8%) | 28 (93.3%) | 2 (6.7%) | 0.928 |
African American | 9 (2.1%) | 8 (88.9%) | 1 (11.1%) | 0.637 |
Middle Eastern | 5 (1.1%) | 5 (100%) | 0 (0%) | 0.998 |
Unknown | 39 (8.9%) | 36 (92.3%) | 3 (7.7%) | 0.875 |
Type of cancer | ||||
Gastrointestinal | 123 (28.1%) | 118 (95.9%) | 5 (4.1%) | 0.132 |
Brain | 109 (24.9%) | 107 (98.2%) | 2 (1.8%) | 0.026** |
Lung | 102 (23.2%) | 90 (88.2%) | 12 (11.8%) | 0.039** |
Breast | 51 (11.6%) | 45 (88.2%) | 6 (11.8%) | 0.172 |
Genitourinary | 18 (4.1%) | 15 (83.3%) | 3 (16.7%) | 0.120 |
Head and neck | 10 (2.3%) | 9 (90.0%) | 1 (10.0%) | 0.717 |
Gynecologic | 7 (1.6%) | 6 (85.7%) | 1 (14.3%) | 0.465 |
Melanoma | 5 (1.1%) | 4 (80.0%) | 1 (20.0%) | 0.285 |
Hematologic | 3 (0.7%) | 3 (100%) | 0 (0%) | 0.998 |
Othera | 10 (2.3%) | 10 (100%) | 0 (0%) | 0.998 |
Presence of metastasis or recurrence at the time of blood draw | ||||
Yes | 312 (71.2%) | 284 (91.0%) | 28 (9.0%) | 0.024** |
No | 126 (28.8%) | 123 (97.6%) | 3 (2.4%) | |