Fig. 2From: Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangementsEffects of HMA and cytostatic drug combinations. Cells were treated with HMA in the absence or presence of AraC (a) or Doxo (b). Cytostatic drugs (CTX) were added simultaneously, 24 h before, or 24 h after treatment with HMA. CTX concentrations were based on low doses and used as follows: 100 nM AZA (SEM), 500 nM AZA (RS4;11), 100 nM DEC (SEM), 500 nM DEC (RS4;11); 10 nM AraC (SEM); 2500 nM AraC (RS4;11), 12.5 nM Doxo (SEM, RS4;11). The metabolic activity was determined 72 h after drug application. Significant effects are marked with * when metabolic activity decreased significantly (p < 0.05) compared at once to DMSO, HMA, and CTXBack to article page