Multiple functions of m6A RNA methylation in cancer

Table 1 Multiple functions exerted by m⁶A RNA methylation in various cancers

Molecule	Role in cancer	Cancer	Biological function	Mechanism	Refs
METTL3	Oncogene	AML	Promote tumorigenesis	Promote MYC et al. translation	[43]
	Oncogene	BC	Promote tumor growth	Promote HBXIP translation	[68]
	Oncogene	HCC	Promote tumor growth	Promote SOCS2 degradation	[70]
	Suppressor gene	GBM	Suppress tumorigenesis	Downregulate ADAM19	[58]
METTL14	Oncogene	AML	Promote tumorigenesis	Stabilize MYC and MYB	[44]
	Suppressor gene	HCC	Suppress metastasis	Promote miR126 processing	[71]
	Suppressor gene	GBM	Suppress tumorigenesis	Downregulate ADAM19	[58]
NSun2	Oncogene	CRC	Promote migration	Suppress miR125b processing	[73]
FTO	Oncogene	AML	Promote tumorigenesis	Destabilize ASB2 and RARA	[52]
FTO	Oncogene	AML	Promote tumorigenesis	Stabilize MYC and CEBPA	[47]
ALKBH5	Oncogene	GBM	Promote tumorigenesis	Stabilize FOXM1 mRNA	[61]
ALKBH5	Oncogene	BC	Promote tumorigenesis	Stabilize NANOG and KLF4	[57]
YTHDF2	Oncogene	PC	Promote tumor growth	Activate Akt/GSK3b/CyclinD1	[75]
YTHDF2	Suppressor gene		Suppress metastasis	Destabilize YAP mRNAs	[75]

ISSN: 1756-8722