Fig. 3

Inhibition of mitochondria transfer decreases the effects of MSC-induced chemoresistance. a, b Cytochalasin D (1 μM) was added to the coculture system with ara-C or MTX for 48 h. The levels of mitochondrial ROS in Jurkat cells were examined by MitoSOX staining. c The apoptosis rate was determined using annexin V/PI staining and FACS. d The percentages of annexin V-positive cells were calculated. e A CCK-8 assay was used to assess Jurkat cell viability. The data above are presented as the mean ± S.E.M. of three independent experiments (*P < 0.05; **P < 0.01; t test)