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Table 2 Correlation of GD2 expression to clinicopathologic factors of Chinese melanoma patients

From: Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients

Clinico pathologic feature

GD2+ (%)

GD2− (%)

P valuea

Age (year)

 Median (range)

52.7 ± 13.5

51.1 ± 15.2

0.348

Gender n (%)

 Male

69 (48.6)

74 (50.7)

0.722

 Female

73 (51.4)

72 (49.3)

Ulceration n (%)

 Yes

82 (57.7)

84 (57.5)

0.971

 No

60 (42.3)

62 (42.5)

Thickness

 Median (range)

3.5 (0.5,20.0)

3.7 (0.5,19.5)

0.581

TNM stage n (%)

 I (16)

5 (3.5)

11 (7.5)

0.003

 II (109)

41 (28.9)

68 (46.6)

 III (92)

55 (38.7)

37 (25.3)

 IV (71)

41 (28.9)

30 (20.5)

Metastasis

 Yes

96 (67.6)

67 (45.9)

< 0.0001

 No

46 (32.4)

79 (54.1)

Primary site

 Acral (134)

67 (47.2)

67 (45.9)

0.017

 Mucosal (71)

40 (28.2)

31 (21.2)

 CSD (14)

2 (1.4)

12 (8.2)

 Non-CSD (27)

9 (6.3)

18 (12.3)

 Unknown primary (42)

24 (16.9)

18 (12.3)

Survival (months)

 Median (95% CI)

31 (34.1,60.1)

47.1 (21.3,40.7)

< 0.0001

  1. aFor evaluation of age, the two independent sample t test or one-way ANOVA was used. For evaluation of gender, ulceration, and TNM stage, the chi-square tests or Fisher’s exact tests were used. For evaluation of thickness, Mann-Whitney U tests were used. For evaluation of OS time, Log-rank tests were used