A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Table 20 Nuclear receptors are significantly changed in caspase-1 and Sirt1 knockout mice, indicating that caspase-1-Sirt1 pathway negatively regulates nuclear receptor expression

Disease		Tissue/cell type	Number		Upregulated gene	Fold*	Downregulated gene	Fold*	PMID/GEO ID
Disease		Tissue/cell type	Up	Down	Upregulated gene	∆	Downregulated gene	∆	PMID/GEO ID
AopE−/−/Casp1−/− vs. ApoE−/−		Aorta	3	0	NR1A2	1.22			GSE72448
					NR1D2	1.17
					NR2C2	1.19
		Adipose	10	1	NR1A1	1.35	NR6A1	−1.32
					NR1C3	1.84
					NR1F1	1.78
					NR1I3	1.22
					NR2A1	2.24
					NR2B1	1.52
					NR3A1	1.39
					NR3C1	1.41
					NR3C4	1.66
					NR4A2	1.16
Casp1−/−/ASC−/− vs. ASC−/−		White adipose tissue	7	0	NR1A1	1.35			21876127/GSE25205
					NR1C3	1.84
					NR1I3	1.22
					NR2A1	1.17
					NR2B1	1.52
					NR3C4	1.65
					NR4A2	1.16
Sirt1−/− vs. WT		Treg	4	0	NR1B1	1.2			21199917/GSE26425
					NR1F1	1.29
					NR2F6	1.22
					NR4A3	1.29
Cardiac-specific transgenic (Tg-Sirt1) mice		Heart	2	6	NR3C4	1.52	NR1B1	−3.57	22055503/GSE33101
					NR0B2	1.35	NR1B3	−1.25
							NR1F3	−2
							NR1I1	−1.27
							NR2B3	−1.22
							NR2C1	−1.22
NLRP3 mutation	Adult control	PBMC	26	9	NR1B1	1.22	NR1F1	−2.93	–/GSE43553
					NR1B2	1.47	NR1F2	−1.4
					NR1B3	1.43	NR2C1	−1.93
					NR1C2	1.18	NR3C1	−1.38
					NR1C3	1.2	NR3C2	−1.68
					NR1I1	1.73	NR4A1	−1.32
					NR1I2	1.2
					NR2A1	1.53
					NR2B3	1.25
					NR2E1	1.31
					NR2E3	1.57
					NR2F1	1.2
					NR3A1	1.61
					NR3A2	1.28
					NR3B1	1.34
					NR4A3	1.27
					NR5A1	1.42
					NR6A1	1.3
					NR0B2	1.34
	Children control		26	11	NR1A1	1.4	NR1D1	−1.82
					NR1A2	1.24	NR1D2	−1.56
					NR1B1	1.31	NR1F1	−2.53
					NR1B2	1.51	NR2B2	−1.44
					NR1B3	1.49	NR2C1	−2.25
					NR1C3	1.32	NR2C2	−1.29
					NR1I1	1.69	NR3C1	−1.3
					NR1I2	1.27	NR3C2	−1.53
					NR2A1	1.66	NR4A1	−1.37
					NR2A2	1.22	NR4A2	−4.23
					NR2E1	1.21
					NR2E3	1.55
					NR2F1	1.24
					NR2F6	1.26
					NR3A1	1.23
					NR3A2	1.41
					NR3B1	1.65
					NR3C3	1.21
					NR4A3	1.23
					NR5A1	1.41
					NR6A1	1.29
					NR0B2	1.34

Abbreviations: ApoE−/− apolipoprotein E-deficient mice, Casp1−/− caspase-1-deficient mice, HFD high fat diet, ASC−/− PYD and CARD domain-containing deficient mice, Sirt 1−/− sirtuin 1-deficient mice; WT wild-type mice, NLRP3 NLR family pyrin domain containing 3 deficient mice; vs. versus

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