Table 2 Common side effects of different immunotherapies
From: Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia
Targets | Medications | Side effects |
|---|---|---|
CD20 | Rituximab | Most common side effect is mild to moderate infusion reactions. Rare cases of severe mucocutaneous reactions, HBV reactivation, and progressive multifocal leukoencephalopathy |
Ofatumumab | Primarily grade 1 or 2 infusion reactions or infections | |
CD19 | SAR3419 | Dose-limiting reversible severe vision changes associated with corneal changes |
SGN-CD19A | Superficial microcystic keratopathy | |
Blinatumomab | Fever, chills, and hypogammaglobulinemia are common. Serious side effects include CRS and neurotoxicity | |
CD22 | Epratuzumab | Seizure, liver toxicity |
INO | Liver toxicity, veno-occlusive disease in transplant patients | |
CD52 | Alemtuzumab | Severe neutropenia, CMV viremia |