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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles

Fig. 2

Recurrent fusion gene families in ALL. a Twenty-one fusion genes were recurrent in BCP-ALL patients. The fusion genes are plotted along the vertical axis, and the patients are plotted along the horizontal axis by the subtype given at ALL diagnosis. The numbers in the upper panels indicate the number of patients where the expected canonical fusion gene was detected by RNA sequencing in each subtype. The canonical subtype-associated fusion genes are marked in blue, the previously reported fusion genes in ALL are indicated in green, and the novel fusion genes discovered here are indicated in red. b Frequently translocated genes giving rise to expressed fusion genes formed six independent node groups. The nodes representing genes that fused with two different partners are shown with green dots, and genes that can have three or more fusion partners are shown with red dots. In-frame fusion genes are highlighted with a black line

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