Fig. 1

Distribution of validated fusion transcripts among 134 ALL patients. a Number of fusion genes detected per sample in BCP-ALL and T-ALL patients. The vertical axis shows the number of fusion genes identified per sample ranging from zero (no detectable fusion gene) up to four co-expressed fusion genes. b Violin plots showing the number of fusion genes per patient in each ALL subtype. No fusion genes were identified in the single dic(9;20) patient, and thus, this sample is excluded from the plot. The vertical axis shows the number of fusion genes identified per sample. Each dot represents one patient. c Chromosomal location of the 64 unique fusion events. The 5′ fusion gene partners are plotted in the left panel, and the 3′ fusion gene partners are plotted in the right panel together with their respective chromosomal locations. The thickness of the connecting lines reflects the recurrence of the fusion gene. Blue lines represent the canonical fusion genes associated with the t(12;21), t(9;22), or 11q23/MLL subtypes. Green lines represent recurrent non-canonical fusion genes and dashed gray lines represent fusion genes identified in a single patient. d Number of fusion genes per ALL subtype. The bars indicate the number of patients in which a given fusion gene was observed by subtype. The panel to the right of the plot shows the number of patients with any fusion gene out of all of patients belonging to the given subtype. The canonical fusion genes are highlighted in blue. Novel fusion genes discovered in this study are highlighted in red. + = in-frame fusion events. * = intra-chromosomal fusion events