Fig. 6

Interaction between mutant Asxl1 and MN1 overexpression. a According to our patient data, ASXL1 mutation was associated with higher MN1 expression. b Among patients with higher MN1 expression, those with ASXL1 mutation had shorter overall survival than those without this mutation (median 4.5 months vs. not reached). c Asxl1 ^tm/+ had no impact on proliferation of bone marrow cells. d Asxl1 ^tm/+ and wild-type bone marrow cells overexpressed MN1 did not show significant difference in proliferation. e Three independent LTC-IC assays showed that under MN1 overexpression background, Asxl1 ^tm/+ bone marrow cells had higher frequency of long-term culture initiation cells than wild-type controls