Fig. 9

miR-330-3p played its roles in promoting invasion and metastasis of NSCLC cells through modulating the expression of GRIA3 via MAPK/ERK pathway. The expression of GRIA3 was determined by western blotting when cells were treated with MEK inhibitor (U0126) (a) and PI3K inhibitor (LY294002) (b). Representative images (upper) and quantification (lower) of the transwell migration assay (c) and transwell invasion assay (d) of H460 and H1975 cells treated with MEK inhibitor (U0126). Values are mean ± SD; a representative experiment of three was reported *P < 0.05, **P < 0.01, one-way ANOVA test