Fig. 6

miR-330-3p induces tumor metastasis and angiogenesis in BM model. a Immunohistochemical analysis of PCNA, cylinD1, Bcl-2, Bax, caspase3, DNMT1, DNMT3A and DNMT3B expression in tissue sections of GFP-labeled tumors isolated from mice injected with H460 and H1975 cells transfected with NC-LV, OE-miR-330-3p-LV or anti-miR-330-3p-LV. A representative experiment of three was reported. *P < 0.05, **P < 0.01, #P < 0.001, one-way ANOVA test. b Representative images of CD31-positive endothelial cells in the viable tumor tissue of mice. c MRI analysis of metastatic tumors (yellow arrow) in the brain. Representative MRI of tumors is shown